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More than 1,000 articles on the potential therapeutic benefit of molecular hydrogen (“H2”) have been published in medical journals around the world. Lean more about it in our videos.

Clinical Studies at Glance

Blood Circulation

  1. Ishibashi, T. et al., 2020. Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial. PLoS One, 15: e0233484.
  2. LeBaron, T.W. et al., 2020. A novel functional beverage for COVID-19 and other conditions: Hypothesis and preliminary data, increased blood flow , and wound healing. Journal of Translational Science, 6: 1-6.
  3. Sakai, T. et al., 2014. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vascular Health and Risk Management: 10: 591-597.
  4. Sim, M. et al., 2020. Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: A randomized, double-blind, controlled trial. Scientific Reports, 10: 12130.
  5. Tanaka, Y. et al., 2018. Electrolytically generated hydrogen warm water cleanses the keratin-plug clogged hair-pores and promotes the capillary bloodstreams, more markedly than normal warm water does. Medical Gas Research, 8:12-18.

Brain Health

  1. Mizuno, K. et al., 2018. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Medical Gas Research, 7: 247-255.
  2. Nishimaki, K. et al., 2018. Effects of molecular hydrogen assessed by an animal and a randomized clinical study on mild cognitive impairment. Current Alzheimer Research, 15: 482-492.
  3. Yoritaka, A. et al., 2013. Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial. Movement Disorders, 28: 836-839.
  4. Yoritaka, A. et al., 2016. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurology, 16: 66.
  5. Zanini, D. et al., 2020. Hydrogen vs. caffeine for improved alertness in sleep-deprived humans. Neurophysiology, 52: 67-72.

Fitness

  1. Aoki, K., et al., 2012. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2: 12.
  2. Da Ponte, A., et al., 2018. Effects of hydrogen rich water on prolonged intermittent exercise. Journal of Sports Medicine and Physical Fitness, 58: 612-621.
  3. Javorac, D et al., 2020. Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete. F1000Research, 9: 245.
  4. Kawamura, T. et al., 2018. Involvement of neutrophil dynamics and function in exercise-induced muscle damage and delayed-onset muscle soreness: Effect of hydrogen bath. Antioxidants, 7: E127.
  5. LeBaron, T.W. et al., 2019. Acute supplementation with molecular hydrogen benefits submaximal exercise indices. Randomized, double-blinded, placebo-controlled crossover pilot study. Journal of Lifestyle Medicine, 9: 36-43.
  6. Mikami, T. et al., 2019. Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Canadian Journal of Physiology and Pharmacology, 97: 857-862.
  7. Ostojic, S.M. and Stojanovic, M.D., 2014. Hydrogen-rich water affected blood alkalinity in physically active men. Research in Sports Medicine, 22: 49-60.
  8. Ostojic, S.M. et al., 2014. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Journal of Postgraduate Medicine, 126: 188-196.
  9. Todorovic, N. et al., 2020. The effects of supersaturated hydrogen-rich water bathing on biomarkers of muscular damage and soreness perception in young men subjected to high-intensity eccentric exercise. Journal of Sports Medicine, 2020: 8836070.

Skin Conditions

  1. Asada, R. et al., 2019. Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. Medical Gas Research, 9: 68-73.
  2. Ishibashi, T. et al., 2015. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Molecular Medicine Reports, 12: 2757-2764.
  3. Ono, H. et al., 2012b. Hydrogen (H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Medical Gas Research, 2: 14.
  4. Tanaka, Y. et al., 2018. Electrolytically generated hydrogen warm water cleanses the keratin-plug clogged hair-pores and promotes the capillary bloodstreams, more markedly than normal warm water does. Medical Gas Research, 8:12-18.

Metabolic Diseases

  1. Kajiyama, S. et al., 2008. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28: 137-143.
  2. Korovljev, D. et al., 2018. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Irish Journal of Medical Science, 187: 85-89.
  3. Korovljev, D. et al., 2018. Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: a preliminary report. European Geriatric Medicine, 9: 729-730.
  4. Korovljev, D. et al., 2019. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. Clin. Res. Hepatol. Gastroenterol., 43: 688-693.
  5. LeBaron, T.W. et al., 2020. The effects of 24-Week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome: A randomized controlled trial. Diabetes, Metabolic Syndrome and Obesity, 13: 889-896.
  6. Nakao, A. et al., 2010. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome – an open label pilot study. Journal of Clinical Biochemistry and nutrition, 46: 140-149.
  7. Song, G. et al., 2015. Hydrogen activates ATP binding cassette transporter a1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized, and placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism, 100: 27624-2733.
  8. Xia, C. et al., 2013. Effect of hydrogen-rich water on oxidative stress, liver function and viral load in patients with chronic hepatitis B. Clinical and Translational Science, 6: 372-375.

Autoimmune Diseases

  1. Ishibashi, T. et al., 2012. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patient with rheumatoid arthritis: an open-label pilot study. Medical Gas Research, 2: 27.
  2. Ishibashi, T. et al., 2014. Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study. International Immunopharmacology, 21: 468-473.
  3. Ishibashi, T. et al., 2015. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Molecular Medicine Reports, 12:
  4. Zhu, Q. et al., 2018. Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Scientific Reports, 8: 8051.

Cancer

  1. Akagi, J. & Baba, H., 2019. Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. Oncology Reports, 41: 301-311.
  2. Chen, J. et al. 2019. A gallbladder carcinoma patient with pseudo-progressive remission after hydrogen inhalation. OncoTargets and Therapy, 12: 8645-8651.
  3. Chen, J.B. et al., 2019. Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report. World Journal of Clinical Cases, 7: 2065-2074.
  4. Chen, J.B. et al., 2019. “Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients. Medical Gas Research, 9: 115-121.
  5. Chen, J-B. et al., 2020. Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Medical Gas Research, 10: 149-154.
  6. Hirano, S. et al., 2021. Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study. Medical Gas Research, 11: 104-109.
  7. Kang, K.M. et al., 2011. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 1: 11.
  8. Yang, Q. et al., 2017. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Molecular and Clinical Oncology, 7: 891-896.

Kidney Dialysis

  1. Maeda, K. et al., 2016. Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: a prospective observational study. Renal Replacement Therapy, 2: 42-49.
  2. Nakayama, M. et al., 2010. A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrology Dialysis Transplantation, 25: 3026-3033.
  3. Nakayama, M. et al., 2017. Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12-month observation. PLoS One, 12: e0184535.
  4. Nakayama, M. et al., 2018. Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observation study. Scientific Reports, 8: 245.
  5. Terawaki, H. et al., 2013. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Medical Gas Research, 3: 14.
  6. Terawaki, H. et al., 2014. Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. Hemodialysis International., 18: 459-466.

Critical Care

  1. Nagatani, K. et al., 2013. Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Medical Gas Research, 3: 13.
  2. Ono, H. et al., 2012a. A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Medical Gas Research, 2: 21.
  3. Ono, H. et al., 2017. Hydrogen gas inhalation treatment in acute cerebral infarction: A randomized controlled clinical study on safety and neuroprotection. Journal of Stroke and Cerebrovascular Diseases, 26: 2587-2594.
  4. Tamura, T. et al., 2016. Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome – first-in-human pilot study. Circulation Journal, 80: 1870-1873.

Other Conditions

  1. Azuma, T. et al., 2015. Drinking hydrogen-rich water has additive effects on non-surgical periodontal treatment of improving periodontitis: A pilot study. Antioxidants, 4: 513-522.
  2. Guan, W-J. et al., 2020. Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnoea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial. Journal of Thoracic Disease, 12: 4591.
  3. Ito, M., et al., 2011. Open-label trial and randomized, double-blind, placebo-controlled crossover trial of hydrogen enriched water for mitochondrial and inflammatory myopathies. Medical Gas Research, 1: 24.
  4. Li, Q. et al., 2013. Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Medical Gas Research, 3: 20.
  5. Matsumoto, S. et al., 2013. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis / painful bladder syndrome. Urology, 81: 226-230.
  6. Qian, L.R. and Shen, J.L., 2016. Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease. Medical Gas Research, 6: 177-179.
  7. Shimouchi, A. et al., 2009. Breath hydrogen produced by ingestion of commercial hydrogen water and milk. Biomarker Insights, 4: 27-32.
  8. Wang, S-T. et al., 2020. Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients. QJM: International Journal of Medicine, 113 870-875.

Last updated in May 2021

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